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Adenosine is a nucleoside that makes up one of the four nucleotides molecules in DNA and RNA.  Derivatives of adenosine are ubiquitous in nature and play essential roles in many biochemical processes. Yeast derived adenosine has recently been found to be an effective addition to skincare formulations for its potential anti-aging benefits.

This study published in the International Journal of Cosmetic Science evaluated adenosine-containing products for their ability to prevent skin wrinkling. After eight weeks, adenosine-containing products showed significant improvements in skin smoothness and decreased appearance of crow’s feet. Adenosine-containing cream also significantly improved the wrinkles between eyebrows, also known as glabellar lines.

My Favorite Adenosine Containing Products Include:

Dear Klaris Midnight Blue Youth Activating Drop 

pH: 5

Skincare Concern: Fine lines and wrinkles

Suitable for: All skin types

Key Ingredients: SH-Oligopeptide-1, SH-Polypeptide-1, Blueberry Fruit Extract, Guaiazulene, Adenosine 

The Dear Klaris Midnight Blue Youth Activating Drops prevent the signs of aging by nourishing and replenishing the skin. They are designed to encourage cellular activity and activating the skins own renewal mechanisms to help the skin look youthful. It is formulated with the peptides EGF and FGF-2, which are naturally occurring proteins within the skin that decline with age. I recommend this for anyone who wants an anti-aging serum that is looking to incorporate peptides into their routine, in a formula that is safe for sensitive skin and won’t cause any irritation or sensitivity.

You can read my full review here 

PURITO Galacto Niacin 97 Power Essence

pH: 5

Skincare Concern: Fine lines and wrinkles, Pigmentation, Dull Skin

Suitable for: All skin types

Key Ingredients: Galactomyces Ferment Filtrate, Bifida Ferment Lysate, Lactobacillus Ferment, Niacinamide

The Purito Galacto Niacin 97 Power Essence is a lightweight essence with an impressive three fermented ingredients as well as brightening niacinamide and mistletoe leaf extract. The formula contains no preservatives or irritating ingredients and is a great way to incorporate probiotic ingredients into your skincare routine.

You can read my full review here 

Some By Mi AHA BHA PHA 30 Days Miracle Toner

pH: 5.8

Skincare Concern: Blackheads, Acne, Acne Scarring, Oily Skin

Suitable for: Oily and Acne-prone

Key Ingredients: Niacinamide, Papaya Extract, Hyaluronic Acid, Tea Tree Oil, Lactobinonic Acid, Witch Hazel

The Some by Mi AHA BHA PHA 30 Day Miracle Toner is a low pH toner that can be used after cleansing to reduce and balance the skin’s pH level and gently exfoliate the skin. It contains 10,000 ppm of tea tree leaf extract to treat acne, a combination of four different chemical exfoliants to effectively exfoliate and hyaluronic acid, niacinamide, glycerine, and adenosine to moisturize, brighten and condition the skin.

You can read my full review here

Cosrx Ultimate Moisturizing Honey Overnight Mask

pH: 5

Skincare Concern: Dryness

Suitable for: All skin types

Key Ingredients: Propolis Extract, Arginine, Sodium Hyaluronate Allantoin, Honey, Adenosine 

The Cosrx Ultimate Moisturizing Honey Overnight Mask is an occlusive, hydrating sleeping mask that can be used as a moisturizer, an overnight mask, or as a wash-off mask.  This hydrating formula boasts an impressive list of gentle ingredients and leaves skin moisturized, nourished, and glowing.

You can read my full review here 


  • Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS technique. International Journal of Cosmetic Science, 2006.
  • Milady Skincare and Cosmetic Ingredient Dictionary, 4th Edition, 2015.